A The most significant Rhesus antigen in isoimmunization is D.

B D is dominant to d, therefore individuals who are DD or Dd will express the D antigen and are ‘D Rhesus positive’.

C Anti-D should be given to a Rhesus-negative mother if antibodies are found.

D If a primip becomes sensitized in pregnancy, fetal haemolysis by maternal antibodies is likely with resultant fetal anaemia in that pregnancy.

E Anti-c, anti-E and anti-Kell are also potential causes of haemolytic disease.

F Rhesus disease due to anti-D is becoming more common.